Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 3/20 | 0.49 |
| ▸ | CCR1 | P32246 | 2/20 | 0.49 |
| ▸ | CCR4 | P51679 | 2/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
| ▸ | CKS1B | P61024 | 2/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | CCR9 | P51686 | 1/20 | 0.44 |
| ▸ | SLC20A2 | Q08357 | 1/20 | 0.43 |
| ▸ | SLC20A1 | Q8WUM9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29888331 | 0.86 | CYP2C9 (0.63) | KMT2AMEN1ALDH1A1CCR2CYP2C9 | |
| SCHEMBL306095 | 0.86 | CYP2C9 (0.63) | KMT2AMEN1ALDH1A1CCR2CYP2C9 | |
| SCHEMBL10223198 | 0.82 | CCR2 (0.47) | KMT2AMEN1SLC40A1CLK1GAA | |
| SCHEMBL10223220 | 0.82 | MEN1 (0.53) | KMT2AMEN1SLC40A1CLK1GAA | |
| SCHEMBL10223329 | 0.81 | MEN1 (0.52) | KMT2AMEN1SLC40A1GAACCR2 | |
| SCHEMBL12594346 | 0.80 | MEN1 (0.52) | KMT2AMEN1CCR2CCR4CYP2C9 | |
| SCHEMBL1762318 | 0.79 | CYP2C9 (0.58) | KMT2AMEN1SLC40A1CLK1GAA | |
| SCHEMBL4799079 | 0.79 | CCR2 (0.46) | KMT2AMEN1SLC40A1CLK1GAA | |
| SCHEMBL305413 | 0.78 | CCR2 (0.53) | KMT2AMEN1SLC40A1CLK1GAA | |
| SCHEMBL4778194 | 0.78 | CYP2C9 (0.44) | KMT2AMEN1SLC40A1CLK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |