Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.36 |
| ▸ | FEN1 | P39748 | 6/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | RAF1 | P04049 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781242 | 0.89 | NOS1 (0.56) | NOS1ALOX5APFEN1LRRK2PIK3CA | |
| SCHEMBL3757090 | 0.84 | NOS1 (0.59) | NOS1ALOX5APFEN1PIK3CAPIK3R1 | |
| SCHEMBL3766398 | 0.83 | NOS1 (0.58) | NOS1ALOX5APFEN1BRAFPIK3CA | |
| SCHEMBL3764131 | 0.82 | NOS1 (0.61) | NOS1LRRK2PIK3CA | |
| SCHEMBL4781574 | 0.81 | NOS1 (0.56) | NOS1PIK3CACNR1CNR2 | |
| SCHEMBL3758139 | 0.81 | NOS1 (0.63) | NOS1ALOX5APFEN1LRRK2PIK3CA | |
| SCHEMBL3763980 | 0.78 | NOS1 (0.70) | NOS1PIK3CACNR2 | |
| SCHEMBL3760937 | 0.75 | NOS1 (0.68) | NOS1PIK3CACNR2PIK3R1PTPN1 | |
| SCHEMBL3760198 | 0.74 | NOS1 (0.63) | NOS1LRRK2PIK3CA | |
| SCHEMBL3759317 | 0.74 | NOS1 (0.72) | NOS1LRRK2PIK3CACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009079-A2 | SUBSTITUTED PTERIDINES USEFUL FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |