Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.61 |
| ▸ | ATR | Q13535 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.40 |
| ▸ | ADK | P55263 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3765184 | 0.90 | NOS1 (0.64) | NOS1ATRJAK2JAK3MTOR | |
| SCHEMBL3765421 | 0.90 | NOS1 (0.63) | NOS1ATRJAK2JAK3MTOR | |
| SCHEMBL3765436 | 0.90 | NOS1 (0.63) | NOS1ATRJAK2JAK3MTOR | |
| SCHEMBL3762311 | 0.89 | NOS1 (0.56) | NOS1ATRJAK2JAK3MTOR | |
| SCHEMBL3762310 | 0.89 | NOS1 (0.56) | NOS1ATRJAK2JAK3MTOR | |
| SCHEMBL3760595 | 0.84 | NOS1 (0.61) | NOS1ATRJAK2JAK3MTOR | |
| SCHEMBL3760610 | 0.84 | NOS1 (0.61) | NOS1ATRJAK2JAK3MTOR | |
| SCHEMBL3770209 | 0.84 | NOS1 (0.71) | NOS1ATRMTORPIK3CAPIK3CG | |
| SCHEMBL3764319 | 0.83 | NOS1 (0.64) | NOS1ATRMTORPIK3CAPIK3CG | |
| SCHEMBL4458075 | 0.83 | NOS1 (0.64) | NOS1ATRMTORPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009079-A2 | SUBSTITUTED PTERIDINES USEFUL FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | claimed |