Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 2/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13584373 | 0.83 | CENPE (0.52) | CENPES1PR1S1PR5S1PR3XDH | |
| SCHEMBL4767596 | 0.81 | CENPE (0.44) | CENPES1PR1NPC1S1PR5S1PR3 | |
| SCHEMBL13584416 | 0.80 | CENPE (0.62) | CENPES1PR1S1PR5S1PR3XDH | |
| SCHEMBL4837737 | 0.80 | CENPE (0.49) | CENPES1PR1S1PR5S1PR3XDH | |
| SCHEMBL3461278 | 0.78 | CENPE (0.66) | CENPES1PR1S1PR5S1PR3XDH | |
| SCHEMBL4838728 | 0.77 | CENPE (0.45) | CENPES1PR1S1PR5S1PR3XDH | |
| SCHEMBL3461702 | 0.76 | CENPE (0.69) | CENPES1PR1S1PR5S1PR3XDH | |
| SCHEMBL13161463 | 0.76 | CENPE (0.69) | CENPES1PR1S1PR5S1PR3XDH | |
| SCHEMBL13184025 | 0.74 | CENPE (0.40) | CENPES1PR1MAPTTP53 | |
| SCHEMBL13161504 | 0.74 | CENPE (0.68) | CENPES1PR1S1PR5S1PR3XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742907-A4 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1742907-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005107762-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-11-17 | — | — | WO | disclosed |