Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.71 |
| ▸ | PPARG | P37231 | 2/20 | 0.69 |
| ▸ | PPARD | Q03181 | 2/20 | 0.69 |
| ▸ | PPARA | Q07869 | 2/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | HTR1D | P28221 | 1/20 | 0.61 |
| ▸ | HTR1B | P28222 | 1/20 | 0.61 |
| ▸ | HTR1E | P28566 | 1/20 | 0.61 |
| ▸ | HTR1F | P30939 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946427 | 0.94 | HTR6 (0.72) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL945925 | 0.93 | HTR6 (0.69) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL947565 | 0.93 | HTR6 (0.69) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL948631 | 0.93 | HTR6 (0.75) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL948959 | 0.91 | HTR6 (0.65) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL4792918 | 0.91 | HTR6 (0.70) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL947233 | 0.90 | HTR6 (0.60) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL946590 | 0.87 | HTR6 (0.56) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL950479 | 0.87 | PPARG (0.73) | HTR6PPARGPPARDPPARAHTR1A | |
| SCHEMBL947469 | 0.87 | HTR6 (0.74) | HTR6PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581492-B1 | N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | SUVEN LIFE SCIENCES LTD (IN) | 2008-07-16 | — | — | EP | disclosed |