Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.55 |
| ▸ | TNFSF11 | O14788 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR1F | P30939 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776953 | 0.89 | HTR6 (0.63) | HTR6TNFHTR1ADRD2HTR1D | |
| SCHEMBL947109 | 0.82 | TNFSF11 (0.74) | HTR6TNFSF11TNFHTR1ADRD2 | |
| SCHEMBL3563421 | 0.82 | HTR6 (0.76) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL949155 | 0.75 | HTR6 (0.65) | HTR6TNFSF11HTR1ADRD2HTR1D | |
| Hydrochloric Acid SCHEMBL946790 | 0.74 | HTR6 (0.63) | HTR6TNFSF11HTR1ADRD2HTR1D | |
| SCHEMBL5330256 | 0.73 | HTR6 (0.53) | HTR6TNFSF11HTR1ADRD2HTR1D | |
| SCHEMBL3556751 | 0.72 | HTR6 (0.64) | HTR6TNFHTR1ADRD2HTR1D | |
| SCHEMBL948005 | 0.72 | TNF (0.69) | HTR6TNFSF11TNFHTR1ADRD2 | |
| SCHEMBL3552073 | 0.72 | HTR6 (0.66) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL3552252 | 0.71 | HTR6 (0.67) | HTR6HTR1ADRD2HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581492-B1 | N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | SUVEN LIFE SCIENCES LTD (IN) | 2008-07-16 | — | — | EP | claimed |