Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | PRKCG | P05129 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | ROS1 | P08922 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13987258 | 0.90 | PLK4 (0.48) | PLK4AURKAMAPK13PDPK1JAK2 | |
| SCHEMBL13987307 | 0.88 | ROCK1 (0.54) | PLK4AURKAMAPK13PDPK1JAK2 | |
| Hydrochloric Acid SCHEMBL4780398 | 0.87 | ROCK2 (0.53) | PLK4AURKAMAPK13PDPK1JAK2 | |
| SCHEMBL4811050 | 0.83 | PLK4 (0.52) | PLK4AURKAMAPK13PDPK1JAK2 | |
| SCHEMBL5447724 | 0.83 | AURKA (0.49) | PLK4AURKAMAPK13PDPK1JAK2 | |
| SCHEMBL4780382 | 0.81 | PLK4 (0.50) | PLK4AURKAMAPK13PDPK1JAK2 | |
| SCHEMBL13987826 | 0.81 | ROCK2 (0.56) | PLK4AURKAMAPK13PDPK1JAK2 | |
| SCHEMBL4778277 | 0.78 | ROCK2 (0.56) | PLK4AURKAMAPK13PDPK1JAK2 | |
| SCHEMBL4815437 | 0.77 | ROCK2 (0.61) | PLK4AURKAMAPK13PDPK1JAK2 | |
| SCHEMBL14144135 | 0.76 | AURKA (0.49) | PLK4AURKAMAPK13PDPK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462713-B2 | Tricyclic compounds protein kinase inhibitors for enhancing the efficacy of anti-neoplastic agents and radiation therapy | AGOURON PHARMACEUTICALS, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| EP-1947102-A1 | Compositions comprising diazepinoindole derivatives as kinase inhibitors | Pfizer, Inc. (US) | 2008-07-23 | — | — | EP | disclosed |
| US-6967198-B2 | Tricyclic compounds protein kinase inhibitors for enhancing the efficacy of anti-neoplastic agents and radiation therapy | AGOURON PHARMACEUTICALS INC. (US) | 2005-11-22 | — | — | US | disclosed |