Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.49 |
| ▸ | CDK1 | P06493 | 5/20 | 0.49 |
| ▸ | CDK4 | P11802 | 3/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.49 |
| ▸ | CCND1 | P24385 | 2/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 6/20 | 0.45 |
| ▸ | SYK | P43405 | 4/20 | 0.45 |
| ▸ | IGF1R | P08069 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771570 | 0.86 | MAPK8 (0.50) | CDK2CDK1CDK4CCNB1CCNE1 | |
| SCHEMBL4773873 | 0.84 | MAPK8 (0.51) | CDK2CDK1CDK4CCNB1CCNE1 | |
| SCHEMBL4767481 | 0.81 | PTK2 (0.49) | CDK2CDK4MAPK8MAPK9AURKA | |
| SCHEMBL2252164 | 0.79 | P2RX3 (0.51) | CDK2CDK1CDK4CCNB1CCNE1 | |
| SCHEMBL4770594 | 0.78 | MAPK9 (0.51) | CDK2CDK1CDK4CCNB1CCNE1 | |
| SCHEMBL4771563 | 0.77 | EGFR (0.49) | CDK2CDK4MAPK8MAPK9AURKA | |
| SCHEMBL4769925 | 0.76 | AURKA (0.48) | CDK2CDK1CDK4MAPK8MAPK9 | |
| SCHEMBL4772107 | 0.75 | MAPK8 (0.57) | CDK2CDK1CDK4CCNB1CCNE1 | |
| SCHEMBL4825515 | 0.75 | MAPK8 (0.48) | CDK2CDK4MAPK8MAPK9SYK | |
| SCHEMBL4764815 | 0.74 | CHEK1 (0.49) | CDK2CDK4MAPK8MAPK9AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | claimed |