Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 3/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.31 |
| ▸ | MAP1LC3A | Q9H492 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5784190 | 0.87 | KIF11 (0.40) | KIF11KCNH2ACP1HSD17B3KDM4E | |
| SCHEMBL4775734 | 0.87 | KIF11 (0.48) | KIF11KCNH2ACP1HSD17B3KDM4E | |
| SCHEMBL644766 | 0.86 | KIF11 (0.59) | KIF11KCNH2ACP1HSD17B3KDM4E | |
| SCHEMBL5781721 | 0.82 | KIF11 (0.39) | KIF11KCNH2MAOB | |
| SCHEMBL646934 | 0.82 | KIF11 (0.60) | KIF11KCNH2KDM4EMAOBMAP1LC3B | |
| SCHEMBL4775736 | 0.81 | KIF11 (0.39) | KIF11KCNH2ACP1HSD17B3KDM4E | |
| SCHEMBL645343 | 0.81 | KIF11 (0.59) | KIF11KCNH2MAOBMAP1LC3B | |
| SCHEMBL5782022 | 0.80 | KIF11 (0.46) | KIF11KCNH2MAOBMAP1LC3B | |
| SCHEMBL643695 | 0.80 | KIF11 (0.69) | KIF11KCNH2MAOBMAP1LC3B | |
| SCHEMBL644147 | 0.79 | KIF11 (0.56) | KIF11KCNH2KDM4EMAOBMAP1LC3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956908-A2 | CERTAIN COMPOSITIONS AND METHODS OF TREATMENT | Cytokinetics, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007067752-A2 | CERTAIN COMPOSITIONS AND METHODS OF TREATMENT | CYTOKINETICS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |