Leucine

Leucine

SCHEMBL4775846

CC(C)CC(N)C(=O)O.NC(=O)CC(N)C(=O)O

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.78
SLC1A3 P43003 5/20 0.61
SLC1A2 P43004 5/20 0.61
SLC1A1 P43005 5/20 0.52
GRIK1 P39086 7/20 0.47
GRIK2 Q13002 4/20 0.46
GRIA2 P42262 2/20 0.46
GRIA4 P48058 2/20 0.46
GRIK3 Q13003 2/20 0.46
GRIK5 Q16478 2/20 0.46
GRIA1 P42261 1/20 0.46
ALOX15 P16050 1/20 0.45
BLM P54132 1/20 0.45
PMP22 Q01453 1/20 0.45
KMT2A Q03164 1/20 0.45
GRM1 Q13255 1/20 0.43
GRM2 Q14416 1/20 0.43
ANPEP P15144 1/20 0.42
RNPEP Q9H4A4 1/20 0.42
DNPEP Q9ULA0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL6130794 1.00 SLC7A5 (0.78) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL6130796 1.00 SLC7A5 (0.78) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL4775848 1.00 SLC7A5 (0.78) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
D-Leucine SCHEMBL4958590 1.00 SLC7A5 (0.78) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL28146797 0.96 SLC7A5 (0.72) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL27607014 0.92 SLC7A5 (0.67) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL2496434 0.92 SLC7A5 (0.67) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL27563977 0.91 SLC7A5 (0.64) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL998944 0.89 SLC7A5 (0.90) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL998945 0.89 SLC7A5 (0.90) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3737420-A2 STEROIDS AND ANTIBODY-CONJUGATES THEREOF Regeneron Pharmaceuticals, Inc. (US) 2020-11-18 EP disclosed
US-10456736-B2 Method and apparatus for purification and treatment of air PALOZA LLC (US) 2019-10-29 US disclosed
WO-2019136487-A2 STEROIDS AND ANTIBODY-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2019-07-11 WO disclosed
CN-107029517-A Purification and the method and apparatus of processing air 朱潮权 2017-08-11 CN disclosed
US-20170106333-A1 Method and Apparatus for Purification and Treatment of Air PALOZA LLC 2017-04-20 US disclosed
CN-104610454-A HSA-related compositions and methods of use MEDIMMUNE LLC 2015-05-13 CN disclosed
CN-102781960-B HSA-related compositions and methods of use MEDIMMUNE LLC 2014-12-10 CN disclosed
EP-2729570-A2 REAGENT USABLE FOR THE ISOLATION AND/OR PURIFICATION OF NUCLEIC ACIDS Qiagen GmbH (DE) 2014-05-14 EP disclosed
CN-101522706-B Telomerase reverse transcriptase fusion protein, nucleotides encoding same, and uses thereof ANGELETTI P IST RICHERCHE BIO 2013-09-04 CN disclosed
WO-2013004710-A2 REAGENT USABLE FOR THE ISOLATION AND/OR PURIFICATION OF NUCLEIC ACIDS QIAGEN GMBH (DE) 2013-01-10 WO disclosed
EP-1957458-A2 5-(ARYLSULFONYL)-PYRAZOLOPIPERIDINES Elan Pharmaceuticals Inc. (US) 2008-08-20 EP disclosed
WO-2007064914-A2 5-(ARYLSULFONYL)-PYRAZOLOPIPERIDINES ELAN PHARMACEUTICALS, INC. (US) 2007-06-07 WO disclosed
CN-1151761-A Subtilisin BPN' variants with reduced adsorption and increased hydrolysis PROCTER & GAMBLE (US) 1997-06-11 CN disclosed
EP-0476022-A1 CRYSTALLINE R-H-GM-CSF AND METHOD FOR THE PREPARATION SCHERING CORPORATION (US) 1992-03-25 EP disclosed
WO-1990015151-A1 CRYSTALLINE R-H-GM-CSF AND METHOD FOR THE PREPARATION SCHERING CORPORATION (US) 1990-12-13 WO disclosed
EP-0402070-A1 Crystalline r-h-GM-CSF and method for its preparation SCHERING CORPORATION (US) 1990-12-12 EP disclosed
CN-85101907-A The manufacturing of single segment dominent human r gamma-interferon 1987-01-10 CN disclosed