Sugi Predict

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Leucine

Leucine

SCHEMBL4775848

CC(C)C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 1/20 0.78
▸ SLC1A3 P43003 5/20 0.61
▸ SLC1A2 P43004 5/20 0.61
▸ SLC1A1 P43005 5/20 0.52
▸ GRIK1 P39086 7/20 0.47
▸ GRIK2 Q13002 4/20 0.46
▸ GRIA2 P42262 2/20 0.46
▸ GRIA4 P48058 2/20 0.46
▸ GRIK3 Q13003 2/20 0.46
▸ GRIK5 Q16478 2/20 0.46
▸ GRIA1 P42261 1/20 0.46
▸ ALOX15 P16050 1/20 0.45
▸ BLM P54132 1/20 0.45
▸ PMP22 Q01453 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ GRM1 Q13255 1/20 0.43
▸ GRM2 Q14416 1/20 0.43
▸ ANPEP P15144 1/20 0.42
▸ RNPEP Q9H4A4 1/20 0.42
▸ DNPEP Q9ULA0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL6130794 1.00 SLC7A5 (0.78) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL6130796 1.00 SLC7A5 (0.78) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL4775846 1.00 SLC7A5 (0.78) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
D-Leucine SCHEMBL4958590 1.00 SLC7A5 (0.78) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL28146797 0.96 SLC7A5 (0.72) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL27607014 0.92 SLC7A5 (0.67) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL2496434 0.92 SLC7A5 (0.67) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL27563977 0.91 SLC7A5 (0.64) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL998944 0.89 SLC7A5 (0.90) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL998945 0.89 SLC7A5 (0.90) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3447132-B1 HBA1C DEHYDROGENASE KIKKOMAN CORP (JP) 2022-05-18 — — EP disclosed
US-11111517-B2 HbA1c dehydrogenase KIKKOMAN CORPORATION (JP) 2021-09-07 — — US disclosed
EP-3737420-A2 STEROIDS AND ANTIBODY-CONJUGATES THEREOF Regeneron Pharmaceuticals, Inc. (US) 2020-11-18 — — EP disclosed
US-10456736-B2 Method and apparatus for purification and treatment of air PALOZA LLC (US) 2019-10-29 — — US disclosed
WO-2019136487-A2 STEROIDS AND ANTIBODY-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2019-07-11 — — WO disclosed
US-20190119715-A1 HbA1c DEHYDROGENASE KIKKOMAN CORPORATION (JP) 2019-04-25 — — US disclosed
US-9701949-B2 Amadoriase with improved thermostability, gene and recombinant DNA for the amadoriase, and method for production of amadoriase with improved thermostability KIKKOMAN CORPORATION (JP) 2017-07-11 — — US disclosed
US-20170106333-A1 Method and Apparatus for Purification and Treatment of Air PALOZA LLC 2017-04-20 — — US disclosed
US-20140356928-A1 AMADORIASE WITH IMPROVED THERMOSTABILITY, GENE AND RECOMBINANT DNA FOR THE AMADORIASE, AND METHOD FOR PRODUCTION OF AMADORIASE WITH IMPROVED THERMOSTABILITY KIKKOMAN CORPORATION (JP) 2014-12-04 — — US disclosed
EP-2729570-A2 REAGENT USABLE FOR THE ISOLATION AND/OR PURIFICATION OF NUCLEIC ACIDS Qiagen GmbH (DE) 2014-05-14 — — EP disclosed
WO-2013004710-A2 REAGENT USABLE FOR THE ISOLATION AND/OR PURIFICATION OF NUCLEIC ACIDS QIAGEN GMBH (DE) 2013-01-10 — — WO disclosed
EP-1957458-A2 5-(ARYLSULFONYL)-PYRAZOLOPIPERIDINES Elan Pharmaceuticals Inc. (US) 2008-08-20 — — EP disclosed
WO-2007064914-A2 5-(ARYLSULFONYL)-PYRAZOLOPIPERIDINES ELAN PHARMACEUTICALS, INC. (US) 2007-06-07 — — WO disclosed