Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 9/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.50 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ESRRA | P11474 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775888 | 1.00 | PIM1 (0.50) | PIM1PIM2CISD1TTRPIM3 | |
| SCHEMBL5320920 | 0.91 | CISD1 (0.51) | PIM1CISD1RAB9A | |
| SCHEMBL5320923 | 0.91 | CISD1 (0.51) | PIM1CISD1RAB9A | |
| SCHEMBL5326341 | 0.83 | PIM1 (0.52) | PIM1PIM2CISD1PIM3AKR1B1 | |
| SCHEMBL1247642 | 0.78 | PIM1 (0.54) | PIM1PIM2CISD1PIM3AKR1B1 | |
| SCHEMBL1247641 | 0.78 | PIM1 (0.54) | PIM1PIM2CISD1PIM3AKR1B1 | |
| SCHEMBL12891939 | 0.78 | PIM1 (0.54) | PIM1PIM2CISD1PIM3AKR1B1 | |
| SCHEMBL4777741 | 0.77 | PTGER4 (0.48) | HPGDRAB9A | |
| SCHEMBL4781425 | 0.74 | MYC (0.53) | PIM1CISD1RAB9A | |
| SCHEMBL4781421 | 0.74 | MYC (0.53) | PIM1CISD1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007119600-A9 | CARBAZOLE COMPOUND | OTSUKA PHARMA CO LTD (JP) | 2008-05-02 | — | — | WO | disclosed |
| WO-2007119600-A1 | CARBAZOLE COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-10-25 | — | — | WO | disclosed |