Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.43 |
| ▸ | TP53 | P04637 | 9/20 | 0.43 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.38 |
| ▸ | RELA | Q04206 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776105 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2TP53NPC1RAB9AHPGD | |
| SCHEMBL4776418 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2TP53NPC1RAB9AHPGD | |
| SCHEMBL4776424 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2TP53NPC1RAB9AHPGD | |
| SCHEMBL4781129 | 0.87 | FASN (0.42) | SMN1; SMN2TP53NPC1RAB9AHPGD | |
| SCHEMBL4781136 | 0.87 | FASN (0.42) | SMN1; SMN2TP53NPC1RAB9AHPGD | |
| SCHEMBL4143238 | 0.86 | TP53 (0.46) | SMN1; SMN2TP53NPC1RAB9AHPGD | |
| SCHEMBL4143244 | 0.86 | TP53 (0.46) | SMN1; SMN2TP53NPC1RAB9AHPGD | |
| SCHEMBL14291650 | 0.82 | CYP2E1 (0.32) | CYP2E1 | |
| SCHEMBL2244516 | 0.81 | CYP2E1 (0.40) | RAB9APKMMAPTKDM4ELMNA | |
| SCHEMBL4779530 | 0.81 | TP53 (0.43) | SMN1; SMN2TP53NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008017688-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-14 | — | — | WO | claimed |
| WO-2008017688-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-14 | — | — | WO | disclosed |