Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779727 | 0.86 | TP53 (0.41) | TP53ALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL4777615 | 0.81 | CHRNA7 (0.42) | TP53ALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL4778456 | 0.81 | ESR1 (0.56) | LMNAESR1SMN1; SMN2USP7 | |
| SCHEMBL4778476 | 0.76 | TP53 (0.43) | TP53ALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL4779710 | 0.71 | TP53 (0.39) | TP53ALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL27781767 | 0.69 | CYP2C19 (0.58) | MEN1KMT2AKDM4ESMN1; SMN2USP7 | |
| SCHEMBL10340365 | 0.69 | AMY1A (0.50) | ALDH1A1MEN1HPGDKMT2ANPSR1 | |
| SCHEMBL21321935 | 0.68 | APP (0.48) | MAPTSMN1; SMN2 | |
| SCHEMBL19998337 | 0.67 | MAOB (0.50) | MAPT | |
| SCHEMBL15694898 | 0.67 | FLT3 (0.47) | TP53ALDH1A1LMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889617-A1 | Triphenyl modified 5-membered heterocycles and their use as anticancer and antiflammatory agents | Freie Universität Berlin (DE) | 2008-02-20 | — | — | EP | claimed |
| EP-1889617-A1 | Triphenyl modified 5-membered heterocycles and their use as anticancer and antiflammatory agents | Freie Universität Berlin (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2008006626-A1 | TRIPHENYL MODIFIED 5-MEMBERED HETEROCYCLES AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS | FREIE UNIVERSITÄT BERLIN (DE) | 2008-01-17 | — | — | WO | disclosed |