Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 9/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261811 | 0.94 | RAF1 (0.39) | RAF1MAPK14KDM4EMAPTALDH1A1 | |
| SCHEMBL4775187 | 0.85 | KDM4E (0.48) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL4259136 | 0.83 | KDM4E (0.49) | IKBKBKDM4EMAPTNPC1CASP3 | |
| SCHEMBL14434356 | 0.80 | KDM4E (0.43) | RAF1MAPK14KDM4EMAPTALDH1A1 | |
| SCHEMBL4773050 | 0.79 | HDAC1 (0.37) | IKBKBRAF1MAPK14KDM4EMAPT | |
| SCHEMBL13906531 | 0.74 | RAF1 (0.45) | RAF1MAPK14KDM4EMAPTALDH1A1 | |
| SCHEMBL612016 | 0.73 | MAPK14 (0.41) | RAF1MAPK14KDM4EMAPTALDH1A1 | |
| SCHEMBL4147003 | 0.73 | HPGD (0.42) | RAF1MAPK14KDM4EMAPTALDH1A1 | |
| SCHEMBL4166268 | 0.73 | KDM4E (0.41) | RAF1MAPK14KDM4EMAPTNPC1 | |
| SCHEMBL3239031 | 0.72 | KDM4E (0.54) | IKBKBKDM4EMAPTNPC1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986646-A1 | NOVEL AZACYCLY-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | Sanofi-Aventis (FR) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093363-A1 | NOVEL AZACYCLY-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS (DE) | 2007-08-23 | — | — | WO | disclosed |