Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | RAF1 | P04049 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4256835 | 0.94 | KDM4E (0.39) | HDAC1HDAC2HDAC3KDM4EHTT | |
| SCHEMBL4256288 | 0.86 | KDM4E (0.41) | HDAC1HDAC2HDAC3KDM4EHTT | |
| SCHEMBL4166268 | 0.84 | KDM4E (0.41) | KDM4EHTTATMMAPK14RAF1 | |
| SCHEMBL4776291 | 0.79 | IKBKB (0.40) | KDM4EIKBKBCFTRMAPK14RAF1 | |
| SCHEMBL4774820 | 0.77 | MEN1 (0.50) | KDM4EHTTNPC1MAPTCASP3 | |
| SCHEMBL4176316 | 0.76 | KDM4E (0.44) | KDM4EHTTATMIKBKBNPC1 | |
| SCHEMBL4775338 | 0.74 | ALDH1A1 (0.34) | HDAC1HDAC2HDAC3KDM4EHTT | |
| SCHEMBL14434356 | 0.73 | KDM4E (0.43) | KDM4EMAPK14RAF1MAPT | |
| SCHEMBL4261811 | 0.73 | RAF1 (0.39) | KDM4EMAPK14RAF1MAPT | |
| SCHEMBL4776318 | 0.70 | IKBKB (0.35) | KDM4EHTTATMIKBKBCFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986646-A1 | NOVEL AZACYCLY-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | Sanofi-Aventis (FR) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093363-A1 | NOVEL AZACYCLY-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS (DE) | 2007-08-23 | — | — | WO | disclosed |