Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 7/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025759 | 0.92 | KDM2B (0.35) | KDM2BMCHR1DRD4HTTKMT2A | |
| SCHEMBL4029300 | 0.87 | MCHR1 (0.36) | KDM2BMCHR1DRD4HTTKMT2A | |
| SCHEMBL4019064 | 0.86 | HTT (0.36) | KDM2BMCHR1DRD4HTTKMT2A | |
| SCHEMBL4023590 | 0.86 | DRD4 (0.39) | MCHR1DRD4HTTKMT2ACCR3 | |
| SCHEMBL4022127 | 0.85 | KDM2B (0.39) | KDM2BMCHR1DRD4HTTKMT2A | |
| SCHEMBL4023627 | 0.85 | KDM2B (0.39) | KDM2BMCHR1DRD4HTTKMT2A | |
| SCHEMBL13721312 | 0.85 | KDM2B (0.39) | KDM2BMCHR1DRD4HTTKMT2A | |
| SCHEMBL4023629 | 0.85 | KDM2B (0.39) | KDM2BMCHR1DRD4HTTKMT2A | |
| SCHEMBL4751954 | 0.84 | DRD4 (0.44) | KDM2BDRD4HTTKMT2ACCR3 | |
| SCHEMBL4025349 | 0.84 | DRD4 (0.43) | KDM2BDRD4HTTKMT2ACCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |