Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.60 |
| ▸ | DDX3X | O00571 | 2/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | GALK1 | P51570 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777937 | 0.85 | TRPV1 (0.58) | TRPV1CCNE1CDK2CDK5MAPT | |
| Hydrochloric Acid SCHEMBL4780347 | 0.84 | TRPV1 (0.58) | TRPV1CCNE1CDK2CDK5MAPT | |
| SCHEMBL4779521 | 0.84 | TRPV1 (0.55) | TRPV1CCNE1CDK2CDK5MAPT | |
| SCHEMBL4778200 | 0.83 | TRPV1 (0.55) | TRPV1DDX3XCCNE1CDK2CDK5 | |
| SCHEMBL4778198 | 0.83 | TRPV1 (0.55) | TRPV1DDX3X | |
| SCHEMBL4777140 | 0.82 | TRPV1 (0.55) | TRPV1CCNE1CDK2CDK5 | |
| SCHEMBL13151501 | 0.79 | TRPV1 (0.73) | TRPV1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL4778078 | 0.79 | TRPV1 (0.48) | TRPV1CCNE1CDK2CDK5 | |
| SCHEMBL5660097 | 0.79 | TRPV1 (0.71) | TRPV1CCNE1CDK2CDK5 | |
| SCHEMBL4777153 | 0.77 | TRPV1 (0.51) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | claimed |
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | disclosed |