Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 18/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4780347 | 0.89 | TRPV1 (0.58) | TRPV1CYP3A4CCNE1CDK2CDK5 | |
| SCHEMBL4778200 | 0.86 | TRPV1 (0.55) | TRPV1CCNE1CDK2CDK5ALDH1A1 | |
| SCHEMBL4778198 | 0.86 | TRPV1 (0.55) | TRPV1 | |
| SCHEMBL4776317 | 0.85 | TRPV1 (0.60) | TRPV1CCNE1CDK2CDK5MEN1 | |
| SCHEMBL4779521 | 0.82 | TRPV1 (0.55) | TRPV1CCNE1CDK2CDK5MEN1 | |
| SCHEMBL4777153 | 0.79 | TRPV1 (0.51) | TRPV1CYP3A4 | |
| SCHEMBL4780953 | 0.79 | KDM4E (0.44) | TRPV1CYP3A4ALDH1A1MAPTKMT2A | |
| SCHEMBL4780959 | 0.79 | KDM4E (0.44) | TRPV1CYP3A4ALDH1A1MAPTKMT2A | |
| SCHEMBL4779001 | 0.78 | TRPV1 (0.49) | TRPV1CCNE1CDK2CDK5ALDH1A1 | |
| SCHEMBL4777140 | 0.78 | TRPV1 (0.55) | TRPV1CYP3A4CCNE1CDK2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | claimed |
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | disclosed |