Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780166 | 0.84 | AKT1 (0.63) | AKT1RPS6KB1LIMK2AKT2 | |
| SCHEMBL4725174 | 0.84 | AKT1 (0.63) | AKT1RPS6KB1LIMK2AKT2 | |
| SCHEMBL4778819 | 0.82 | AKT1 (0.59) | AKT1RPS6KB1LIMK2AKT2 | |
| SCHEMBL4727707 | 0.76 | AKT2 (0.52) | AKT1BTKKITAKT2BCDIN3D | |
| SCHEMBL1002598 | 0.76 | SLC6A4 (0.52) | AKT1RPS6KB1LIMK2KITAKT2 | |
| SCHEMBL1791316 | 0.74 | HTR3E (0.51) | AKT1RPS6KB1ALDH1A1 | |
| SCHEMBL2782416 | 0.73 | SLC6A4 (0.46) | AKT1RPS6KB1KITAKT2ALDH1A1 | |
| SCHEMBL4727192 | 0.71 | AKT1 (0.73) | AKT1RPS6KB1LIMK2AKT2 | |
| SCHEMBL4778241 | 0.71 | AKT1 (0.60) | AKT1LIMK2AKT2 | |
| SCHEMBL3928238 | 0.70 | AKT2 (0.57) | AKT1BTKKITAKT2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051419-A1 | AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER INC. | 2008-02-28 | — | — | US | disclosed |
| WO-2008012635-A2 | AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051419-A1 | AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | CCNY, CCND2, CCND1 | AKT1 752/4885BTK 1216/4885RPS6KB1 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.