SCHEMBL4776884

SCHEMBL4776884

N#Cc1ccc2cccc(NC(=O)C3CCC(NCc4ccc5c(n4)OC(=O)CN5)CN3)c2n1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.33
PLAU P00749 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4766982 0.86 PLAU (0.32) PLAU
SCHEMBL4507976 0.80 KCNH2 (0.54) KCNH2
SCHEMBL4522945 0.80 KCNH2 (0.54) KCNH2
SCHEMBL4775783 0.80 KCNH2 (0.44) KCNH2
SCHEMBL4501354 0.80 KCNH2 (0.43) KCNH2
SCHEMBL4509702 0.79 KCNH2 (0.35) KCNH2
SCHEMBL4502729 0.74 KCNH2 (0.52) KCNH2
SCHEMBL4520946 0.70 PLAU (0.33) KCNH2PLAU
SCHEMBL4520953 0.70 PLAU (0.33) KCNH2PLAU
SCHEMBL13407412 0.64 KCNH2 (0.51) KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1891078-A1 AMINOPIPERIDINE QUINOLINES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY AstraZeneca AB (SE) 2008-02-27 EP disclosed
WO-2006125974-A1 AMINOPIPERIDINE QUINOLINES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY ASTRAZENECA AB (SE) 2006-11-30 WO disclosed