Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4767895 | 0.94 | AURKA (0.50) | AURKARPS6KB1NPC1RAB9AGAA | |
| SCHEMBL4770662 | 0.89 | MEN1 (0.57) | NPC1RAB9AGAAHRH3SMN1; SMN2 | |
| SCHEMBL4767869 | 0.87 | HRH3 (0.49) | NPC1RAB9AGAAHRH3SMN1; SMN2 | |
| SCHEMBL21468514 | 0.85 | AURKA (0.62) | AURKARPS6KB1NPC1RAB9AGAA | |
| SCHEMBL4768724 | 0.84 | BLM (0.46) | NPC1RAB9AGAAHRH3BLM | |
| Trifluoroacetic Acid SCHEMBL4770119 | 0.84 | MEN1 (0.52) | AURKARPS6KB1NPC1RAB9AGAA | |
| SCHEMBL4777120 | 0.83 | NPY5R (0.54) | NPC1RAB9AHRH3SMN1; SMN2TP53 | |
| SCHEMBL4774558 | 0.80 | NPC1 (0.59) | NPC1RAB9AGAAHRH3SMN1; SMN2 | |
| SCHEMBL4772665 | 0.80 | HRH3 (0.52) | NPC1RAB9AGAAHRH3BLM | |
| SCHEMBL4770392 | 0.80 | HRH3 (0.59) | NPC1RAB9AHRH3SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |