Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.45 |
| ▸ | PDE4A | P27815 | 9/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.45 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758725 | 0.78 | PDE10A (0.55) | PDE4BPDE10APDE4APDE3BPDE3A | |
| SCHEMBL3270119 | 0.77 | PDE10A (0.60) | PDE4BPDE10APDE4APDE3BPDE3A | |
| SCHEMBL24951298 | 0.74 | PDE10A (0.64) | PDE4BPDE10APDE4APDE3BPDE3A | |
| SCHEMBL1758630 | 0.73 | PDE10A (0.46) | PDE4BPDE10APDE4APDE3BPDE3A | |
| SCHEMBL3270008 | 0.72 | NOX1 (0.46) | NOX1MAPTNPSR1MAPK1KDM4E | |
| SCHEMBL3269569 | 0.72 | PDE10A (0.56) | PDE4BPDE10APDE4APDE3BPDE3A | |
| SCHEMBL6076416 | 0.72 | MAPK14 (0.51) | PDE4BPDE10APDE4AMAPT | |
| SCHEMBL17443554 | 0.71 | GSTP1 (0.56) | MAPTNPSR1MAPK1KDM4EHSP90AA1 | |
| SCHEMBL188012 | 0.70 | PDE10A (0.63) | PDE4BPDE10APDE4APDE3BPDE3A | |
| SCHEMBL4780878 | 0.69 | MAOB (0.49) | PDE4BPDE10APDE4APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008001182-A1 | TRICYCLIC HETEROARYL COMPOUNDS AS PDE10 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-01-03 | — | — | WO | disclosed |
| WO-2008001182-A1 | TRICYCLIC HETEROARYL COMPOUNDS AS PDE10 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-01-03 | — | — | WO | disclosed |