Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1893318 | 0.90 | CHEK2 (0.42) | PDGFRAKITIRAK4FGFR4FGFR2 | |
| SCHEMBL1890510 | 0.86 | FGFR4 (0.56) | PDGFRAKITFGFR4FGFR2FGFR1 | |
| SCHEMBL14540826 | 0.86 | ALK (0.39) | PDGFRAKITIRAK4FGFR4FGFR2 | |
| SCHEMBL1892921 | 0.85 | FFAR4 (0.38) | ABL1SRCABL2 | |
| SCHEMBL1894711 | 0.83 | IRAK4 (0.45) | PDGFRAKITIRAK4FGFR4FGFR2 | |
| SCHEMBL14540824 | 0.82 | MET (0.40) | PDGFRAKITIRAK4FGFR4FGFR2 | |
| SCHEMBL12503695 | 0.82 | CSF1R (0.44) | PDGFRAKITIRAK4METAXL | |
| SCHEMBL1895889 | 0.79 | FGFR4 (0.58) | PDGFRAKITFGFR4FGFR2FGFR1 | |
| SCHEMBL1894126 | 0.78 | PDGFRB (0.43) | PDGFRAMETAXLPDGFRBFLT4 | |
| SCHEMBL1894128 | 0.78 | ABL1 (0.47) | PDGFRAKITIRAK4FGFR4FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1777218-B1 | Process for the preparation of 4-phenoxy quinoline derivatives | EISAI R&D MAN CO LTD (JP) | 2008-12-31 | — | — | EP | disclosed |