SCHEMBL4777475

SCHEMBL4777475

[CH2]C1OC(=O)OC1CCCC

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.38
FASN P49327 1/20 0.38
DAGLA Q9Y4D2 1/20 0.34
CYP1A2 P05177 2/20 0.33
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
PKM P14618 1/20 0.32
HPGD P15428 1/20 0.32
KMT2A Q03164 1/20 0.32
KAT2A Q92830 2/20 0.32
GRM2 Q14416 1/20 0.31
PRKCA P17252 1/20 0.31
TP53 P04637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4304636 0.88 KAT2A (0.41) POLBFASNKAT2A
SCHEMBL4304676 0.79
SCHEMBL2949970 0.76 POLB (0.36) POLBFASNDAGLACYP1A2KDM4E
SCHEMBL23528827 0.73 POLB (0.33) POLBFASNDAGLACYP1A2KDM4E
SCHEMBL17589655 0.72 POLB (0.41) POLBFASNDAGLACYP1A2PRKCA
SCHEMBL8935521 0.71 KAT2A (0.42) POLBFASNDAGLACYP1A2KAT2A
SCHEMBL7689986 0.71
SCHEMBL7699936 0.71 PRKCA (0.50) POLBFASNDAGLACYP1A2PRKCA
SCHEMBL2953958 0.71 POLB (0.41) POLBFASNDAGLACYP1A2PRKCA
SCHEMBL2949950 0.69 POLB (0.43) POLBFASNDAGLACYP1A2PRKCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114615999-B Drug antibody conjugates 法马马有限公司 2024-03-08 CN disclosed
CN-114615999-A Drug antibody conjugates 法马马有限公司 2022-06-10 CN disclosed
EP-1919290-A2 METHODS AND PRODUCTS FOR TREATMENT OF DISEASES DMI Biosciences, Inc. (US) 2008-05-14 EP disclosed
WO-2007009087-A2 METHODS AND PRODUCTS FOR TREATMENT OF DISEASES DMI BIOSCIENCES, INC. (US) 2007-01-18 WO disclosed
CN-1798576-A Drug for preventing or treating angiogenic eye diseases SANKYO CO (JP) 2006-07-05 CN disclosed
EP-1336407-B1 COMPOSITION CONTAINING AN ANGIOTENSIN II RECEPTOR ANTAGONIST AND A DIURETIC AND ITS USE FOR THE TREATMENT OF HYPERTENSION SANKYO CO (JP) 2006-05-03 EP disclosed
CN-1165533-C Spiropiperidine derivatives ������������ʽ���� 2004-09-08 CN disclosed
EP-1377577-A1 PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES Sankyo Company Limited (JP) 2004-01-07 EP disclosed
WO-2003106435-A1 FUSED-RING PYRIMIDIN-4(3H)-ONE DERIVATIVES, PROCESSES FOR THE PREPARATION AND USES THEREOF SANKYO COMPANY, LIMITED (JP) 2003-12-24 WO disclosed
EP-1336407-A1 MEDICINAL COMPOSITIONS Sankyo Company, Limited (JP) 2003-08-20 EP disclosed
WO-2003066633-A1 NOVEL PYRANOSYL CYTOSINES: PHARMACEUTICAL FORMULATIONS AND METHODS ISIS PHARMACEUTICALS, INC. (US) 2003-08-14 WO disclosed
WO-2002057264-A1 PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES SANKYO COMPANY LIMITED (JP) 2002-07-25 WO disclosed
CN-1304402-A Sulfonamide derivatives SANKYO CO (JP) 2001-07-18 CN disclosed
CN-1294588-A Spiropiperidine derivatives SANKYO CO (JP) 2001-05-09 CN disclosed
WO-2001002413-A1 BAFIlOMYCIN DERIVATIVES WITH ANTICANCER ACTIVITY INSTITUTO BIOMAR S.A. (ES) 2001-01-11 WO disclosed
EP-0763053-A4 STEROID DERIVATIVES FOR TREATMENT OF 5 ALPHA REDUCTASE SMITHKLINE BEECHAM CORP (US) 1998-09-09 EP disclosed
EP-0763053-A1 STEROID DERIVATIVES FOR TREATMENT OF 5 ALPHA REDUCTASE SMITHKLINE BEECHAM CORPORATION (US) 1997-03-19 EP disclosed
WO-1995033761-A1 STEROID DERIVATIVES FOR TREATMENT OF 5 ALPHA REDUCTASE SMITHKLINE BEECHAM CORPORATION (US) 1995-12-14 WO disclosed