Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774735 | 0.76 | MEN1 (0.39) | MEN1KMT2ARORCCYP1A2CYP3A4 | |
| SCHEMBL4021407 | 0.76 | RORC (0.45) | MEN1KMT2ARORCCYP1A2CYP3A4 | |
| SCHEMBL4018682 | 0.76 | RORC (0.45) | MEN1KMT2ARORCCYP1A2CYP3A4 | |
| SCHEMBL4780182 | 0.76 | KMT2A (0.39) | MEN1KMT2ARORCCYP1A2CYP3A4 | |
| SCHEMBL4024300 | 0.76 | KMT2A (0.39) | MEN1KMT2ARORCCYP1A2CYP3A4 | |
| SCHEMBL4025606 | 0.76 | KMT2A (0.39) | MEN1KMT2ARORCCYP1A2CYP3A4 | |
| SCHEMBL4024451 | 0.69 | RORC (0.43) | MEN1KMT2ARORCCYP1A2CYP3A4 | |
| SCHEMBL4774167 | 0.69 | RORC (0.43) | MEN1KMT2ARORCCYP1A2CYP3A4 | |
| SCHEMBL4022028 | 0.68 | KMT2A (0.61) | MEN1KMT2AALDH1A1L3MBTL1GAA | |
| SCHEMBL28585318 | 0.68 | HDAC4 (0.50) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |