Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 3/20 | 0.32 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3290246 | 0.87 | MEN1 (0.40) | FGFR4SLC6A2CACNA2D1CSF1RMEN1 | |
| SCHEMBL3291782 | 0.72 | ALDH1A1 (0.44) | SLC6A2CACNA2D1TSHRMEN1KMT2A | |
| SCHEMBL891655 | 0.65 | TSHR (0.47) | CYP17A1TSHRSTING1KMT2AHCAR1 | |
| SCHEMBL11101244 | 0.63 | KMT2A (0.46) | MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL9956454 | 0.62 | MEN1 (0.47) | SLC6A2CACNA2D1MEN1KMT2ACCNA2 | |
| SCHEMBL3528616 | 0.61 | SLC6A2 (0.41) | SLC6A2CACNA2D1TSHRMEN1KMT2A | |
| SCHEMBL3534676 | 0.61 | KMT2A (0.45) | MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL2289695 | 0.61 | CACNA2D1 (0.51) | SLC6A2CACNA2D1MEN1KMT2A | |
| SCHEMBL2289702 | 0.61 | CACNA2D1 (0.51) | SLC6A2CACNA2D1MEN1KMT2A | |
| SCHEMBL3291780 | 0.60 | MEN1 (0.44) | TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |