Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776416 | 0.80 | MAPT (0.42) | MAPTTSHRRECQLNPSR1SIGMAR1 | |
| SCHEMBL4778781 | 0.76 | MAPT (0.39) | MAPTTSHRRECQLNPSR1SIGMAR1 | |
| SCHEMBL27662579 | 0.72 | PDE10A (0.39) | MAPTTSHRRECQLNPSR1SIGMAR1 | |
| SCHEMBL27662580 | 0.72 | MAPT (0.36) | MAPTTSHRRECQLNPSR1SIGMAR1 | |
| SCHEMBL4776347 | 0.72 | CYP11B2 (0.38) | MAPTTSHRRECQLNPSR1SIGMAR1 | |
| SCHEMBL4772232 | 0.71 | MAPT (0.35) | MAPTTSHRRECQLNPSR1SIGMAR1 | |
| SCHEMBL1818787 | 0.70 | MAPT (0.40) | MAPTTSHRRECQLNPSR1CYP11B2 | |
| SCHEMBL4778082 | 0.70 | SLC22A12 (0.35) | MAPTTSHRRECQLNPSR1SIGMAR1 | |
| SCHEMBL4776499 | 0.69 | HTT (0.40) | MAPTTSHRRECQLNPSR1SIGMAR1 | |
| SCHEMBL4776498 | 0.69 | HTT (0.40) | MAPTTSHRRECQLNPSR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763528-B1 | PYRAZOLOPYRIDINE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2008-11-26 | — | — | EP | disclosed |