⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10581622 | 0.82 | CES1 (0.41) | — | |
| SCHEMBL3160334 | 0.77 | HDAC3 (0.39) | — | |
| SCHEMBL11306443 | 0.72 | — | — | |
| SCHEMBL1685807 | 0.69 | TSHR (0.40) | — | |
| SCHEMBL11603989 | 0.68 | CA1 (0.39) | — | |
| SCHEMBL27835211 | 0.67 | — | — | |
| SCHEMBL1267259 | 0.66 | — | — | |
| SCHEMBL9731067 | 0.66 | — | — | |
| SCHEMBL2951344 | 0.66 | — | — | |
| SCHEMBL724425 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1892239-B1 | Inhibitors of cytosolic phospholipase A2 | WYETH LLC (US) | 2013-02-20 | — | — | EP | disclosed |
| EP-1892239-A1 | Inhibitors of cytosolic phospholipase A2 | Wyeth a Corporation of the State of Delaware (US) | 2008-02-27 | — | — | EP | disclosed |
| EP-1451154-B1 | INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | WYETH CORP (US) | 2008-01-16 | — | — | EP | disclosed |
| EP-1451154-A2 | INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | Wyeth (US) | 2004-09-01 | — | — | EP | disclosed |
| US-6635771-B2 | Useful as intermediates in the synthesis of compounds having activity as chemical inhibitors of various phospholipase enzymes, particularly phospholipase A2 | WYETH | 2003-10-21 | — | — | US | disclosed |
| US-20030158405-A1 | Chemical intermediates for making a phospholipase enzyme inhibitors | WYETH | 2003-08-21 | — | — | US | disclosed |
| WO-2003048122-A2 | INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | WYETH (US) | 2003-06-12 | — | — | WO | disclosed |