Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4725253 | 0.99 | KCNH2 (0.38) | KCNH2CHRM2CHRM1SLC6A3MEN1 | |
| SCHEMBL4727424 | 0.84 | CHRM2 (0.39) | KCNH2CHRM2CHRM1SLC6A3MEN1 | |
| SCHEMBL4725244 | 0.83 | KCNH2 (0.36) | KCNH2CHRM2CHRM1SLC6A3MEN1 | |
| Bromide SCHEMBL4795145 | 0.83 | LMNA (0.40) | KCNH2CHRM2CHRM1SLC6A3MEN1 | |
| SCHEMBL4779634 | 0.83 | CHRM3 (0.39) | KCNH2CHRM2CHRM1SLC6A3MEN1 | |
| Bromide SCHEMBL4725231 | 0.82 | CHRM3 (0.38) | KCNH2CHRM2CHRM1SLC6A3MEN1 | |
| SCHEMBL14291870 | 0.82 | KCNH2 (0.38) | KCNH2CHRM2CHRM1SLC6A3MEN1 | |
| SCHEMBL4727311 | 0.82 | KCNH2 (0.39) | KCNH2CHRM2CHRM1SLC6A3MEN1 | |
| SCHEMBL524278 | 0.82 | KCNH2 (0.39) | KCNH2CHRM2CHRM1SLC6A3MEN1 | |
| SCHEMBL4726296 | 0.82 | KCNH2 (0.39) | KCNH2CHRM2CHRM1SLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023157-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS M3-RECEPTOR MODULATORS | ARGENTA DISCOVERY LIMITED (GB) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008023157-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS M3-RECEPTOR MODULATORS | ARGENTA DISCOVERY LIMITED (GB) | 2008-02-28 | — | — | WO | disclosed |