Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.43 |
| ▸ | GABRP | O00591 | 6/20 | 0.43 |
| ▸ | GABRD | O14764 | 6/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.43 |
| ▸ | GABRE | P78334 | 6/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1971939 | 0.88 | MAPK1 (0.61) | MAPK1KDM4EL3MBTL1CYP1A2GABRA1 | |
| SCHEMBL29637478 | 0.88 | MAPK1 (0.61) | MAPK1KDM4EL3MBTL1CYP1A2GABRA1 | |
| SCHEMBL27476383 | 0.83 | MAPK1 (0.75) | MAPK1KDM4EL3MBTL1GABRA1GABRG2 | |
| SCHEMBL1018980 | 0.83 | POLB (0.47) | KDM4EL3MBTL1CYP1A2GABRA1GABRG2 | |
| SCHEMBL370722 | 0.81 | P4HTM (0.59) | MAPK1KDM4EL3MBTL1CYP1A2GABRA1 | |
| SCHEMBL17668766 | 0.81 | MAPK1 (0.68) | MAPK1KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL16998556 | 0.81 | MAPK1 (0.53) | MAPK1KDM4EL3MBTL1CYP1A2GABRA1 | |
| SCHEMBL18608207 | 0.81 | CA1 (0.63) | MAPK1CYP1A2CA12CA1CA2 | |
| SCHEMBL15932872 | 0.81 | CYP1A2 (0.44) | MAPK1KDM4ECYP1A2GABRA1GABRG2 | |
| SCHEMBL11386893 | 0.80 | MAPK1 (0.51) | MAPK1KDM4EL3MBTL1CYP1A2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968976-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007068619-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-06-21 | — | — | WO | disclosed |