Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SI | P14410 | 1/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6110390 | 1.00 | MGAM (0.45) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL7903603 | 0.98 | MGAM (0.47) | MGAMGAASIMGAM2KMT2A | |
| Cyclohexanol SCHEMBL4410504 | 0.94 | MGAM (0.40) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL31206650 | 0.93 | GAA (0.52) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL19569796 | 0.86 | KMT2A (0.50) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL3256401 | 0.86 | KMT2A (0.50) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL3252087 | 0.86 | KMT2A (0.50) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL3251414 | 0.86 | KMT2A (0.50) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL5672230 | 0.84 | EPHX2 (0.42) | MGAMGAASIMGAM2EPHX1 | |
| SCHEMBL3248382 | 0.84 | KMT2A (0.51) | MGAMGAASIMGAM2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
| US-7105558-B2 | Gastrin and cholecystokinin receptor lignads (iv) | THE JAMES BLACK FOUNDATION LIMITED (GB) | 2006-09-12 | — | — | US | disclosed |
| US-20030195237-A1 | Gastrin and cholecystokinin receptor lignads (iv) | JAMES BLACK FOUNDATION LIMITED (GB) | 2003-10-16 | — | — | US | disclosed |
| WO-2001085704-A1 | GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS (IV) | JAMES BLACK FOUNDATION LIMITED (GB) | 2001-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195237-A1 | Gastrin and cholecystokinin receptor lignads (iv) | CCKAR, CCKBR, GRPR | MGAM 4260/4885GAA 4667/4885SI 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.