Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779366 | 0.84 | P2RX7 (0.45) | P2RX7SMN1; SMN2LMNAKDM4ENPSR1 | |
| SCHEMBL12944004 | 0.77 | P2RX7 (0.53) | P2RX7SMN1; SMN2NPSR1NPC1RAB9A | |
| SCHEMBL6361128 | 0.75 | P2RX7 (0.64) | P2RX7SMN1; SMN2LMNANPSR1NPC1 | |
| SCHEMBL5067379 | 0.74 | P2RX7 (0.56) | P2RX7SMN1; SMN2NPSR1NPC1RAB9A | |
| SCHEMBL8380160 | 0.73 | NPC1 (0.53) | P2RX7SMN1; SMN2NPSR1NPC1RAB9A | |
| SCHEMBL5798126 | 0.73 | NPC1 (0.53) | P2RX7SMN1; SMN2NPSR1NPC1RAB9A | |
| SCHEMBL4777622 | 0.72 | NPC1 (0.57) | SMN1; SMN2LMNAKDM4ENPC1RAB9A | |
| SCHEMBL6293580 | 0.72 | P2RX7 (0.54) | P2RX7SMN1; SMN2NPSR1NPC1RAB9A | |
| SCHEMBL4378400 | 0.72 | P2RX7 (0.54) | P2RX7SMN1; SMN2LMNANPSR1NPC1 | |
| SCHEMBL6293582 | 0.72 | P2RX7 (0.54) | P2RX7SMN1; SMN2NPSR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008016676-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |