Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1849729 | 0.91 | RAB9A (0.62) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL1848693 | 0.88 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL1847760 | 0.84 | USP2 (0.70) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL224315 | 0.83 | NPC1 (0.83) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL224762 | 0.83 | NPC1 (0.88) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL11365372 | 0.83 | SMN1; SMN2 (0.64) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL1346046 | 0.83 | SMN1; SMN2 (0.64) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL4477551 | 0.82 | JAK2 (0.51) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL1347033 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL1438230 | 0.81 | GSK3B (0.54) | SMN1; SMN2RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889617-A1 | Triphenyl modified 5-membered heterocycles and their use as anticancer and antiflammatory agents | Freie Universität Berlin (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2008006626-A1 | TRIPHENYL MODIFIED 5-MEMBERED HETEROCYCLES AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS | FREIE UNIVERSITÄT BERLIN (DE) | 2008-01-17 | — | — | WO | disclosed |