SCHEMBL4779638

SCHEMBL4779638

COc1cc2ncn(C(C)C)c(=O)c2cc1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 3/20 0.47
TSHR P16473 2/20 0.44
MAPK1 P28482 1/20 0.44
TNF P01375 4/20 0.42
CCNB2 O95067 1/20 0.40
CDK1 P06493 1/20 0.40
CCNB1 P14635 1/20 0.40
CCNB3 Q8WWL7 1/20 0.40
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
GAA P10253 1/20 0.39
HTT P42858 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13504952 0.81 HDAC6 (0.41) HDAC6TSHRMAPK1TNFHDAC3
SCHEMBL4782862 0.81 HDAC6 (0.51) HDAC6TSHRMAPK1TNFHDAC3
SCHEMBL4796792 0.76 HDAC6 (0.48) HDAC6TSHRMAPK1TNFHDAC3
SCHEMBL19645655 0.75 HDAC6 (0.51) HDAC6TSHRMAPK1TNFHDAC3
SCHEMBL4725517 0.75 ELANE (0.50) HDAC6HTTEGFRATM
SCHEMBL4781276 0.74 ACVR1 (0.44) HDAC6TSHRMAPK1TNFGAA
SCHEMBL4783088 0.74 HDAC6 (0.43) HDAC6TSHRMAPK1TNFHDAC3
SCHEMBL4781320 0.74 HDAC6 (0.55) HDAC6TSHRMAPK1TNFHDAC3
SCHEMBL1227184 0.72 HDAC6 (0.60) HDAC6TNFHDAC3HDAC4HDAC1
SCHEMBL5124722 0.71 HDAC6 (0.62) HDAC6TNFHDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008020302-A2 HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS PFIZER PRODUCTS INC. (US) 2008-02-21 WO disclosed