Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | DAO | P14920 | 2/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7691155 | 0.83 | MAPKAPK2 (0.54) | MAPKAPK2RPS6KA3CSNK2A1PLK3NPC1 | |
| SCHEMBL10470663 | 0.79 | CA12 (0.47) | NPC1RAB9APOLBALDH1A1DAO | |
| SCHEMBL9901885 | 0.75 | MAPK1 (0.49) | NPC1RAB9APOLBALDH1A1DAO | |
| Acetic Acid SCHEMBL7846202 | 0.75 | MAPKAPK2 (0.46) | MAPKAPK2RPS6KA3CSNK2A1PLK3NPC1 | |
| SCHEMBL10423642 | 0.73 | NPC1 (0.50) | NPC1RAB9APOLBALDH1A1PDGFRB | |
| SCHEMBL6647315 | 0.72 | NPC1 (0.62) | NPC1RAB9APOLBALDH1A1PDGFRB | |
| SCHEMBL10524583 | 0.71 | CA12 (0.42) | NPC1RAB9APOLBALDH1A1DAO | |
| SCHEMBL15639557 | 0.71 | MEN1 (0.46) | MAPKAPK2RPS6KA3CSNK2A1PLK3NPC1 | |
| SCHEMBL9379605 | 0.71 | ALDH1A1 (0.57) | MAPKAPK2RPS6KA3CSNK2A1PLK3NPC1 | |
| SCHEMBL28696302 | 0.71 | CCR1 (0.41) | MAPKAPK2RPS6KA3CSNK2A1PLK3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041264-A1 | ISOINDOLO-QUINOXALINE DERIVATIVES HAVING ANTITUMOR ACTIVITY, PROCESS FOR THEIR PRODUCTION AND THEIR USE | UNIVERSITA' DEGLI STUDI DI PALERMO (IT) | 2008-04-10 | — | — | WO | disclosed |