Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | AR | P10275 | 1/20 | 0.88 |
| ▸ | RAB9A | P51151 | 1/20 | 0.88 |
| ▸ | HPGD | P15428 | 6/20 | 0.73 |
| ▸ | HTT | P42858 | 5/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.45 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784543 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2ARRAB9AHPGDHTT | |
| SCHEMBL4783580 | 0.98 | SMN1; SMN2 (0.97) | SMN1; SMN2ARRAB9AHPGDHTT | |
| SCHEMBL14863160 | 0.94 | RAB9A (1.00) | SMN1; SMN2ARRAB9AHPGDHTT | |
| SCHEMBL4785098 | 0.84 | HPGD (0.94) | SMN1; SMN2ARRAB9AHPGDHTT | |
| SCHEMBL4783422 | 0.84 | HPGD (0.94) | SMN1; SMN2ARRAB9AHPGDHTT | |
| SCHEMBL948758 | 0.83 | HPGD (0.70) | SMN1; SMN2ARRAB9AHPGDHTT | |
| SCHEMBL4803313 | 0.82 | SMN1; SMN2 (0.70) | SMN1; SMN2ARRAB9AHPGDHTT | |
| SCHEMBL4785255 | 0.82 | SMN1; SMN2 (0.70) | SMN1; SMN2ARRAB9AHPGDHTT | |
| SCHEMBL4783720 | 0.82 | HPGD (0.91) | SMN1; SMN2ARRAB9AHPGDHTT | |
| SCHEMBL4783677 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2ARRAB9AHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064136-A2 | COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS | ACADIA PHARMACEUTICALS INC. (US) | 2008-05-29 | — | — | WO | disclosed |