Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.52 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2902043 | 1.00 | GCK (0.52) | GCKKCNH2S1PR2MEN1GAA | |
| SCHEMBL2898939 | 0.90 | GCK (0.53) | GCKKCNH2MEN1GAAHTT | |
| SCHEMBL1147005 | 0.90 | GCK (0.53) | GCKKCNH2 | |
| SCHEMBL13891563 | 0.90 | GCK (0.53) | GCKKCNH2 | |
| SCHEMBL13292214 | 0.88 | GCK (0.54) | GCKKCNH2MEN1GAAHTT | |
| SCHEMBL2174199 | 0.86 | GCK (0.67) | GCKKCNH2 | |
| SCHEMBL2085635 | 0.85 | GCK (0.43) | GCKKCNH2S1PR2 | |
| SCHEMBL2087153 | 0.85 | GCK (0.43) | GCKKCNH2S1PR2 | |
| SCHEMBL2654104 | 0.83 | GCK (0.79) | GCKKCNH2 | |
| SCHEMBL4779278 | 0.83 | GCK (0.79) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1992623-A1 | Heteroaryl benzamide derivative for use as GLK activator in the treatment of diabetes | Astra Zeneca AB (SE) | 2008-11-19 | — | — | EP | disclosed |