Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 19/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2085635 | 1.00 | GCK (0.43) | GCKKCNH2S1PR2 | |
| SCHEMBL2654956 | 0.90 | GCK (0.44) | GCKKCNH2 | |
| SCHEMBL2652964 | 0.88 | GCK (0.54) | GCKKCNH2 | |
| SCHEMBL13891563 | 0.87 | GCK (0.53) | GCKKCNH2 | |
| SCHEMBL1147005 | 0.87 | GCK (0.53) | GCKKCNH2 | |
| SCHEMBL2654209 | 0.85 | GCK (0.65) | GCKKCNH2 | |
| SCHEMBL2902043 | 0.85 | GCK (0.52) | GCKKCNH2S1PR2 | |
| SCHEMBL4779901 | 0.85 | GCK (0.52) | GCKKCNH2S1PR2 | |
| SCHEMBL2660755 | 0.85 | GCK (0.51) | GCKKCNH2 | |
| SCHEMBL2905733 | 0.85 | GCK (0.63) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059941-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4,5B] PYRIDINE/PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | ASTRAZENECA AB (SE) | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059941-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4,5B] PYRIDINE/PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | GCK, PDXK, GCKR | GCK 1/4885KCNH2 438/4885S1PR2 1420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.