Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780071 | 0.91 | PIN1 (0.41) | ALDH1A1MAPTPIN1PIN4L3MBTL1 | |
| SCHEMBL4777868 | 0.90 | DDB1 (0.36) | KAT2B | |
| SCHEMBL4778754 | 0.85 | CYP19A1 (0.35) | TNF | |
| SCHEMBL4776701 | 0.83 | DDB1 (0.38) | ALDH1A1LMNAPOLBTNFPPARG | |
| SCHEMBL4775564 | 0.83 | CYP19A1 (0.37) | KMT2AMEN1TNF | |
| SCHEMBL4780184 | 0.83 | DDB1 (0.33) | LMNATNF | |
| SCHEMBL4778652 | 0.83 | CRBN (0.34) | ALDH1A1ALOX15TNF | |
| SCHEMBL633548 | 0.82 | CYP2C19 (0.39) | CYP2C19HIF1ACYP2D6ALDH1A1MAPT | |
| SCHEMBL4780107 | 0.81 | HTT (0.34) | ALDH1A1L3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL6755164 | 0.81 | TNF (0.30) | TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524742-B2 | Use of 5H-thioeno(3,4-c)pyrrole-4,6-dione derivatives as tumor necrosis factor inhibitor | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2013-09-03 | — | — | US | disclosed |
| US-8524742-B2 | Use of 5H-thioeno(3,4-c)pyrrole-4,6-dione derivatives as tumor necrosis factor inhibitor | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2013-09-03 | — | — | US | disclosed |
| US-8524742-B2 | Use of 5H-thioeno(3,4-c)pyrrole-4,6-dione derivatives as tumor necrosis factor inhibitor | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2013-09-03 | — | — | US | disclosed |
| US-20120220631-A1 | USE OF 5H-THIOENO(3,4-c)PYRROLE-4,6-DIONE DERIVATIVES AS TUMOR NECROSIS FACTOR INHIBITOR | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2012-08-30 | — | — | US | disclosed |
| US-20120220631-A1 | USE OF 5H-THIOENO(3,4-c)PYRROLE-4,6-DIONE DERIVATIVES AS TUMOR NECROSIS FACTOR INHIBITOR | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2012-08-30 | — | — | US | disclosed |
| US-20120220631-A1 | USE OF 5H-THIOENO(3,4-c)PYRROLE-4,6-DIONE DERIVATIVES AS TUMOR NECROSIS FACTOR INHIBITOR | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2012-08-30 | — | — | US | disclosed |
| US-8183260-B2 | small molecule, low toxicity, high efficiency, high economic value; 5-(2,6-dioxopiperidin-3-yl)-5H-thieno(3,4-c)pyrrole-4,6-dione: | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2012-05-22 | — | — | US | disclosed |
| US-8183260-B2 | small molecule, low toxicity, high efficiency, high economic value; 5-(2,6-dioxopiperidin-3-yl)-5H-thieno(3,4-c)pyrrole-4,6-dione: | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2012-05-22 | — | — | US | disclosed |
| US-8183260-B2 | small molecule, low toxicity, high efficiency, high economic value; 5-(2,6-dioxopiperidin-3-yl)-5H-thieno(3,4-c)pyrrole-4,6-dione: | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2012-05-22 | — | — | US | disclosed |
| EP-1964842-A1 | 5H-THIENO [3,4-c]PYRROLE-4, 6-DIONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR | Tian Jin Hemay Bio-Tech Co., Ltd. (CN) | 2008-09-03 | — | — | EP | disclosed |
| US-20080176900-A1 | 5H-THIOENO(3,4-c)PYRROLE-4,6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2008-07-24 | — | — | US | disclosed |
| US-20080176900-A1 | 5H-THIOENO(3,4-c)PYRROLE-4,6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2008-07-24 | — | — | US | disclosed |
| US-20080176900-A1 | 5H-THIOENO(3,4-c)PYRROLE-4,6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220631-A1 | USE OF 5H-THIOENO(3,4-c)PYRROLE-4,6-DIONE DERIVATIVES AS TUMOR NECROSIS FACTOR INHIBITOR | TNF, TPMT, TNFRSF1A | CYP2C19 1488/4885HIF1A 649/4885CYP2D6 1102/4885 |
| US-20080176900-A1 | 5H-THIOENO(3,4-c)PYRROLE-4,6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TNF, TNFRSF1A, CD40 | CYP2C19 2457/4885HIF1A 660/4885CYP2D6 1891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.