Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | MARK3 | P27448 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730814 | 0.94 | CDK2 (0.52) | AURKACDK2MAPTCHEK1IKBKB | |
| SCHEMBL14292759 | 0.91 | AURKA (0.59) | AURKACDK2MAPTCHEK1IKBKB | |
| SCHEMBL14293021 | 0.90 | AURKA (0.51) | AURKACDK2CHEK1NPC1PDPK1 | |
| SCHEMBL4726143 | 0.87 | AURKA (0.56) | AURKACDK2MAPTCHEK1IKBKB | |
| SCHEMBL4725761 | 0.87 | AURKA (0.51) | AURKACDK2MAPTCHEK1IKBKB | |
| SCHEMBL4797882 | 0.87 | CDK4 (0.51) | CDK2MAPTNPC1CDK1MAPK1 | |
| SCHEMBL14292623 | 0.86 | MAPT (0.62) | CDK2MAPTNPC1MAPK1RAB9A | |
| SCHEMBL14292444 | 0.86 | HTT (0.46) | AURKACDK2CDK1FAAHCYP2D6 | |
| SCHEMBL14293051 | 0.85 | MAPK8 (0.47) | AURKACDK2MAPTNPC1MAPK1 | |
| SCHEMBL14292066 | 0.85 | AURKA (0.55) | AURKACDK2MAPTCHEK1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |