Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CCNH | P51946 | 1/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4801761 | 0.91 | CDK2 (0.50) | CDK4CDK2IGF1RMAPTNPC1 | |
| SCHEMBL14292515 | 0.90 | FAAH (0.53) | CDK4CDK2IGF1RMAPTNPC1 | |
| SCHEMBL14292821 | 0.90 | FAAH (0.53) | CDK4CDK2IGF1RMAPTNPC1 | |
| SCHEMBL14292524 | 0.90 | FAAH (0.53) | CDK4CDK2IGF1RMAPTNPC1 | |
| SCHEMBL14293021 | 0.90 | AURKA (0.51) | CDK4CDK2NPC1CDK1MAPK1 | |
| SCHEMBL14292650 | 0.87 | AURKA (0.52) | CDK4CDK2IGF1RMAPTNPC1 | |
| SCHEMBL4779928 | 0.87 | AURKA (0.52) | CDK4CDK2MAPTNPC1CDK1 | |
| SCHEMBL14292620 | 0.86 | EGFR (0.61) | CDK2IGF1RMAPTCDK1MAPK1 | |
| SCHEMBL4730814 | 0.85 | CDK2 (0.52) | CDK4CDK2MAPTNPC1CDK1 | |
| SCHEMBL14292617 | 0.85 | SLC2A1 (0.52) | CDK4CDK2SMG1SYKEPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |