Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 18/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 17/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | SGK1 | O00141 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | DMPK | Q09013 | 1/20 | 0.46 |
| ▸ | MYLK | Q15746 | 1/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727253 | 0.89 | ROCK1 (0.48) | ROCK1ROCK2ATG4BGSK3B | |
| SCHEMBL4726280 | 0.89 | ROCK1 (0.58) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| SCHEMBL4725338 | 0.89 | ROCK1 (0.54) | ROCK1ROCK2SGK1AKT1GSK3B | |
| SCHEMBL4779953 | 0.89 | ROCK1 (0.58) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| SCHEMBL4726587 | 0.88 | ROCK1 (0.50) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| SCHEMBL4776809 | 0.85 | ROCK1 (0.46) | ROCK1ROCK2SGK1AKT1GSK3B | |
| SCHEMBL4726466 | 0.84 | ROCK1 (0.49) | ROCK1ROCK2SGK1AKT1GSK3B | |
| SCHEMBL4779141 | 0.84 | ROCK1 (0.49) | ROCK1ROCK2ATG4BSGK1AKT1 | |
| SCHEMBL4777271 | 0.83 | ROCK1 (0.48) | ROCK1ROCK2AKT1GSK3BLIMK1 | |
| Hydrochloric Acid SCHEMBL4725358 | 0.83 | ROCK1 (0.49) | ROCK1ROCK2ATG4BSGK1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716320-B2 | Antibacteriall heterocyclic ureas | REPLIDYNE, INC. (US) | 2014-05-06 | — | — | US | claimed |
| US-20080207703-A1 | Antibacterial heterocyclic ureas | REPLIDYNE, INC. (US) | 2008-08-28 | — | — | US | claimed |
| WO-2008011191-A1 | ANTIBACTERIAL HETEROCYCLIC UREAS | REPLIDYNE, INC. (US) | 2008-01-24 | — | — | WO | claimed |
| US-8716320-B2 | Antibacteriall heterocyclic ureas | REPLIDYNE, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20080207703-A1 | Antibacterial heterocyclic ureas | REPLIDYNE, INC. (US) | 2008-08-28 | — | — | US | disclosed |
| WO-2008011191-A1 | ANTIBACTERIAL HETEROCYCLIC UREAS | REPLIDYNE, INC. (US) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207703-A1 | Antibacterial heterocyclic ureas | UMPS, UROD, UGP2 | ROCK1 4331/4885ROCK2 4405/4885ATG4B 729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.