Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 8/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CCR4 | P51679 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CCR5 | P51681 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR9 | P51686 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10223387 | 0.95 | CCR2 (0.54) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL12594756 | 0.91 | CCR2 (0.51) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL10223665 | 0.90 | CCR9 (0.56) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL306793 | 0.90 | CCR2 (0.67) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL29888412 | 0.90 | CCR2 (0.67) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL10223328 | 0.88 | CCR2 (0.57) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL10223329 | 0.88 | MEN1 (0.52) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL10223391 | 0.87 | CCR2 (0.56) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL305031 | 0.85 | CYP2C9 (0.60) | CCR2CYP3A4CYP2C9CYP2C19CCR4 | |
| SCHEMBL10223235 | 0.84 | CCR2 (0.56) | CCR2CYP3A4CYP2C9CYP2C19CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |