Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.64 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 4/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14205784 | 0.89 | HTR2A (0.63) | HTR2ADRD2HTR2CRBP4MEN1 | |
| SCHEMBL4781253 | 0.89 | HTR2A (0.61) | HTR2ADRD2HTR2CRBP4MEN1 | |
| SCHEMBL4784635 | 0.85 | HTR2A (0.67) | HTR2ADRD2HTR2CKCNH2 | |
| SCHEMBL4782835 | 0.82 | HTR2A (0.64) | HTR2ADRD2HTR2CRBP4GRM2 | |
| SCHEMBL4848833 | 0.82 | HTR2A (0.63) | HTR2ADRD2HTR2CRBP4MEN1 | |
| SCHEMBL27249713 | 0.80 | HTR2A (0.66) | HTR2ADRD2RBP4MEN1KMT2A | |
| SCHEMBL29573378 | 0.78 | HTR2A (0.78) | HTR2AHTR2CSLC6A3KCNH2ALDH1A1 | |
| SCHEMBL29573813 | 0.78 | HTR2A (1.00) | HTR2AHTR2CSLC6A3KCNH2 | |
| SCHEMBL3130316 | 0.78 | HTR2A (1.00) | HTR2AHTR2CSLC6A3KCNH2 | |
| SCHEMBL3139382 | 0.78 | HTR2A (0.78) | HTR2AHTR2CSLC6A3KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | claimed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |