Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14205784 | 0.89 | HTR2A (0.63) | HTR2ADRD2THRBLMNAMEN1 | |
| SCHEMBL4781253 | 0.89 | HTR2A (0.61) | HTR2ADRD2MEN1KMT2AKCNH2 | |
| SCHEMBL14205788 | 0.87 | HTR2A (0.48) | HTR2ADRD2THRBLMNAMEN1 | |
| SCHEMBL4783869 | 0.85 | HTR2A (0.68) | HTR2ADRD2THRBMEN1KMT2A | |
| SCHEMBL27249713 | 0.83 | HTR2A (0.66) | HTR2ADRD2MEN1KMT2ARBP4 | |
| SCHEMBL4780625 | 0.82 | HTR2A (0.64) | HTR2ADRD2MEN1KMT2AKCNH2 | |
| SCHEMBL4782835 | 0.80 | HTR2A (0.64) | HTR2ADRD2LMNAMEN1KMT2A | |
| SCHEMBL27249712 | 0.78 | DRD2 (0.60) | HTR2ADRD2MEN1KMT2ARBP4 | |
| SCHEMBL4781375 | 0.78 | PTGS1 (0.58) | HTR2ADRD2MEN1KMT2AKCNH2 | |
| SCHEMBL3138755 | 0.77 | HTR2A (0.79) | HTR2ATHRBLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |