Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GLA | P06280 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.31 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780474 | 0.78 | EGFR (0.43) | MEN1KMT2AP2RX7CYP2C9 | |
| SCHEMBL4780649 | 0.77 | AURKA (0.42) | KDM4EGAAALDH1A1MAPTLMNA | |
| SCHEMBL3195817 | 0.71 | TLR8 (0.50) | MEN1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL21676217 | 0.68 | GRIN2D (0.66) | KDM4EGLAGAAALDH1A1PIM1 | |
| SCHEMBL22198956 | 0.67 | GRIN2D (0.46) | KDM4EGLAGAAALDH1A1PIM1 | |
| SCHEMBL19957217 | 0.67 | HSD17B10 (0.51) | KDM4EALDH1A1MAPTARMEN1 | |
| SCHEMBL19431846 | 0.65 | TLR8 (0.47) | MEN1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL22185666 | 0.65 | GRIN2D (0.44) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL22185226 | 0.64 | GRIN2D (0.42) | KDM4EGAAALDH1A1MAPTLMNA | |
| SCHEMBL6116673 | 0.63 | TNKS (0.46) | KDM4EALDH1A1MAPTGRIA1CACNG8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |