Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780649 | 0.91 | AURKA (0.42) | EGFRP2RX7KMT2AMEN1IGF1R | |
| SCHEMBL4796798 | 0.83 | EGFR (0.47) | EGFRGPR84KMT2AMEN1AURKA | |
| SCHEMBL4792506 | 0.80 | EGFR (0.48) | EGFRGPR84KMT2AMEN1IGF1R | |
| SCHEMBL4780810 | 0.78 | KDM4E (0.36) | P2RX7KMT2AMEN1CYP2C9 | |
| SCHEMBL4779044 | 0.76 | AURKA (0.42) | EGFRKMT2AMEN1IGF1RAURKA | |
| SCHEMBL4782136 | 0.74 | MAPT (0.45) | KMT2AMEN1IGF1RCYP1A2CYP3A4 | |
| SCHEMBL4781252 | 0.73 | KDM4E (0.52) | KMT2AMEN1IGF1RCYP1A2CYP3A4 | |
| SCHEMBL4780633 | 0.70 | AURKA (0.49) | EGFRGPR84KMT2AMEN1IGF1R | |
| SCHEMBL4795408 | 0.70 | AURKA (0.49) | EGFRKMT2AMEN1IGF1RAURKA | |
| SCHEMBL4780820 | 0.69 | AURKA (0.44) | EGFRKMT2AMEN1IGF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | claimed |
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |