SCHEMBL4781180

SCHEMBL4781180

[3H]C(CCN)C(C)Nc1cc(OC)c(OC)c2ccc(CCCC)nc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.42
HSP90AB1 P08238 1/20 0.42
RAD52 P43351 1/20 0.40
KDM4E B2RXH2 1/20 0.40
NSD2 O96028 1/20 0.40
MAPT P10636 1/20 0.40
PABPC1 P11940 1/20 0.39
CASP7 P55210 1/20 0.39
CASP6 P55212 1/20 0.39
MAOA P21397 15/20 0.38
MAOB P27338 15/20 0.38
ABCB11 O95342 1/20 0.36
ESR1 P03372 1/20 0.36
CYP1A2 P05177 1/20 0.36
PGR P06401 1/20 0.36
ADRB2 P07550 1/20 0.36
CHRM2 P08172 1/20 0.36
ADRB1 P08588 1/20 0.36
HTR1A P08908 1/20 0.36
ADRA2A P08913 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5080779 0.74 HSP90AA1 (0.53) HSP90AA1HSP90AB1KDM4ENSD2MAPT
SCHEMBL5086467 0.73 HSP90AA1 (0.51) HSP90AA1HSP90AB1KDM4ENSD2MAPT
SCHEMBL5083233 0.69 HSP90AA1 (0.49) HSP90AA1HSP90AB1KDM4ENSD2MAPT
SCHEMBL6404447 0.69 MAOA (0.45) RAD52KDM4ENSD2MAPTCASP7
SCHEMBL10949657 0.66 KDM4E (0.64) HSP90AA1HSP90AB1RAD52KDM4ENSD2
SCHEMBL5083304 0.65 MAOA (0.49) HSP90AA1HSP90AB1RAD52KDM4ENSD2
SCHEMBL4730513 0.65 KDM4E (0.68) HSP90AA1HSP90AB1RAD52KDM4ENSD2
SCHEMBL4730492 0.62 MAOA (0.77) HSP90AA1HSP90AB1KDM4ENSD2MAPT
SCHEMBL28795328 0.61 KDM4E (0.39) HSP90AB1KDM4EMAPTNQO2PDE4A
SCHEMBL4729708 0.61 MAOA (0.67) HSP90AA1HSP90AB1RAD52KDM4ENSD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008021210-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS COMBINATORX, INCORPORATED (US) 2008-02-21 WO disclosed