Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.66 |
| ▸ | HTR2C | P28335 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | AHR | P35869 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14205207 | 0.91 | HTR2A (0.56) | HTR2AHTR2CALDH1A1MAPTMAPK8 | |
| SCHEMBL4784431 | 0.89 | HTR2A (0.66) | HTR2AHTR2CALDH1A1KCNH2AHR | |
| SCHEMBL4781852 | 0.89 | HTR2A (0.66) | HTR2AHTR2CALDH1A1KCNH2AHR | |
| SCHEMBL4782575 | 0.86 | HTR2A (0.65) | HTR2AHTR2CALDH1A1KCNH2TSHR | |
| SCHEMBL4732167 | 0.85 | HTR2A (0.65) | HTR2AHTR2CALDH1A1KCNH2 | |
| SCHEMBL4731508 | 0.85 | HTR2A (0.65) | HTR2AHTR2CALDH1A1KCNH2 | |
| SCHEMBL4794769 | 0.85 | HTR2A (0.67) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4783248 | 0.85 | HTR2A (0.67) | HTR2AHTR2CMAPTKCNH2 | |
| SCHEMBL4782015 | 0.85 | HTR2A (0.61) | HTR2AHTR2CMAPTKCNH2 | |
| SCHEMBL4782121 | 0.85 | HTR2A (0.61) | HTR2AHTR2CMAPK8MAPK10KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | claimed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |